PBLD

Across TCGA patient cohorts, PBLD mutation is significantly associated with the RNA expression of many other genes, with 1,345 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PBLD-associated genes across cancer lineages are MIR7845, MRPL32P1, and OR4A5. Each is linked with PBLD in more than 2 cancer types. Because this analysis shows association rather than direction, both PBLD-to-partner and partner-to-PBLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7845 grouped by PBLD-low versus PBLD-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBLD→partner) and Y-score (partner→PBLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR7845 →	+0.615	+3.944	<.001	.007	3	3
BLCA	MRPL32P1 →	+0.109	+4.147	<.001	.009	3	2
BLCA	OR4A5 →	+0.058	+5.040	<.001	.002	3	2
BLCA	PHKG1P2 →	+0.060	+5.307	<.001	.001	3	2
CESC	OR6K2 →	+0.031	+5.252	<.001	.002	3	2
SKCM	PRC1 →	+0.764	+3.491	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,345 associations by consensus.

MIR7845 by PBLD expression — CESC

Explore this box plot interactively →