PBK

Across TCGA pan-cancer cohorts, PBK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PBK data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PBK mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PBK expression acts as an unfavorable survival marker.

PDAC, LUAD, and CCRCC are the cancer types where PBK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.513	0.973	.008	41	view →
LUAD	OS	Tertile	All	0.660	0.908	.003	12	view →
CCRCC	DFS	Median	All	0.397	1.000	.038	2	view →
HNSC	DFS	Quartile	III,IV	0.355	0.855	.024	2	view →
UCEC	DFS	Median	All	0.849	0.951	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PBK–PDAC (OS)

Open the PDAC breakdown →