PBK

Across TCGA pan-cancer cohorts, PBK mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PBK’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PBK mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PBK is over-expressed in tumor.

LSCC, HNSC, and LUAD are the cancer types where PBK tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PBK mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.988	<.001	8	view →
HNSC	All	III,IV	+0.337	<.001	8	view →
LUAD	All	All	+0.237	<.001	7	view →
CCRCC	Male	All	+0.611	<.001	6	view →
PDAC	All	All	+0.458	.002	4	view →
COAD	All	All	+0.245	.003	4	view →
OV	All	All	+0.806	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PBK–LSCC

Open the LSCC breakdown →