PBK

Across TCGA patient cohorts, PBK protein abundance is significantly associated with the RNA expression of many other genes, with 17,972 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PBK-associated genes across cancer lineages are CENPI, MCM4, and NEIL3. Each is linked with PBK in more than 8 cancer types. Because this analysis shows association rather than direction, both PBK-to-partner and partner-to-PBK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PBK versus CENPI in LUAD, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBK→partner) and Y-score (partner→PBK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CENPI →	+1.113	+0.702	<.001	<.001	3	9
LUAD	MCM4 →	+0.998	+0.614	<.001	<.001	3	9
GBM	NEIL3 →	+1.031	+0.607	<.001	<.001	3	9
UCEC	NCAPG →	+1.333	+0.791	<.001	<.001	3	9
LSCC	RFC5 →	+0.770	+0.537	<.001	<.001	3	9
UCEC	TTK →	+1.384	+0.722	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,972 associations by consensus.

PBK vs CENPI — LUAD

Explore this scatter interactively →