PBDC1

Across TCGA pan-cancer cohorts, PBDC1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PBDC1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PBDC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PBDC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where PBDC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	IV	0.784	0.138	.024	7	view →
PDAC	DFS	Quartile	III,IV	0.998	0.541	.011	7	view →
HNSC	DFS	Tertile	III,IV	1.000	0.911	.036	3	view →
GBM	DFS	Tertile	All	0.521	0.281	.045	2	view →
UCEC	OS	Quartile	All	0.860	1.000	.034	2	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.871	.032	1	view →
LSCC	DFS	Median	II,III,IV	0.872	0.698	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PBDC1–CCRCC (DFS)

Open the CCRCC breakdown →