PAXBP1

Across TCGA patient cohorts, PAXBP1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAXBP1-associated genes across cancer lineages are ATM, Annexin-1, and 14-3-3_beta. Each is linked with PAXBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAXBP1-to-partner and partner-to-PAXBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PAXBP1-low versus PAXBP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAXBP1→partner) and Y-score (partner→PAXBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.578	-3.321	<.001	.009	3	3
UCEC	Annexin-1 →	+0.611	+2.584	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.107	-2.636	<.001	<.001	3	2
UCEC	PCNA →	+0.244	+1.807	<.001	<.001	3	2
UCEC	PDK1_pS241 →	+0.108	+1.736	.033	.006	3	2
UCEC	PKC-delta_pS664 →	-0.071	-1.184	.047	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ATM by PAXBP1 expression — COAD

Explore this box plot interactively →