PAXBP1

Across TCGA cell cohorts, PAXBP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,164 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PAXBP1-associated GO terms across cancer lineages are Positive regulation of DNA metabolic process, Positive regulation of double-strand break repair, and Regulation of microtubule-based process. Each is linked with PAXBP1 in more than 18 cancer types. Because this analysis shows association rather than direction, both PAXBP1-to-partner and partner-to-PAXBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA metabolic process grouped by PAXBP1-low versus PAXBP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAXBP1→partner) and Y-score (partner→PAXBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA metabolic process →	+0.073	+0.938	<.001	<.001	3	19
LUNG_SCLC	Positive regulation of double-strand break repair →	+0.085	+1.000	<.001	<.001	3	19
LUNG_SCLC	Regulation of microtubule-based process →	+0.084	+1.222	<.001	<.001	3	18
LUNG_SCLC	Regulation of DNA repair →	+0.067	+1.238	<.001	<.001	3	18
LUNG_SCLC	Subtelomeric heterochromatin formation →	+0.139	+1.163	<.001	<.001	3	17
BONE	Heterochromatin formation →	+0.093	+1.386	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,164 associations by consensus.

Positive regulation of DNA metabolic process by PAXBP1 expression — BONE

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