PAXBP1

Across TCGA cell cohorts, PAXBP1 mutation is significantly associated with the RNA expression of many other genes, with 371 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAXBP1-associated genes across cancer lineages are OR10A6, MAGEB4, and OR10H3. Each is linked with PAXBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAXBP1-to-partner and partner-to-PAXBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A6 grouped by PAXBP1-low versus PAXBP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAXBP1→partner) and Y-score (partner→PAXBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	2
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.192	<.001	.002	3	2
KIDNEY	OR10H3 →	+0.049	+5.000	<.001	.005	3	1
BLOOD_Leukemia	APCS →	+0.128	+5.201	<.001	.006	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 371 associations by consensus.

OR10A6 by PAXBP1 expression — BLOOD_Leukemia

Explore this box plot interactively →