PAX8

Across TCGA patient cohorts, PAX8 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,094 significant associations in total. KIRP shows the largest number of these associations.

The most reproducible PAX8-associated GO terms across cancer lineages are Distal convoluted tubule development, Negative regulation of somatic stem cell population maintenance, and Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis. Each is linked with PAX8 in more than 27 cancer types. Because this analysis shows association rather than direction, both PAX8-to-partner and partner-to-PAX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Distal convoluted tubule development grouped by PAX8-low versus PAX8-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX8→partner) and Y-score (partner→PAX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Distal convoluted tubule development →	+1.366	+2.051	<.001	<.001	3	28
LAML	Negative regulation of somatic stem cell population maintenance →	+1.911	+2.349	<.001	<.001	3	20
LAML	Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis →	-0.202	-2.137	<.001	<.001	3	19
DLBC	Otic vesicle development →	+0.054	+1.107	.002	.001	3	18
ESCA	Pronephros development →	+0.060	+0.642	<.001	<.001	3	17
UCS	Metanephric distal tubule development →	+0.101	+2.388	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,094 associations by consensus.

Distal convoluted tubule development by PAX8 expression — LAML

Explore this box plot interactively →