PAX8

Across TCGA patient cohorts, PAX8 mutation is significantly associated with the RNA expression of many other genes, with 2,018 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX8-associated genes across cancer lineages are RNU1-62P, RNU6-258P, and RN7SKP56. Each is linked with PAX8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAX8-to-partner and partner-to-PAX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-62P grouped by PAX8-low versus PAX8-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX8→partner) and Y-score (partner→PAX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-62P →	+0.185	+4.539	<.001	.008	3	2
LUSC	RNU6-258P →	+0.307	+4.578	<.001	.005	3	2
CESC	RN7SKP56 →	+0.151	+4.503	<.001	.005	3	2
SKCM	SRIP1 →	+0.084	+3.495	<.001	.003	3	2
UCEC	PLBD2 →	+0.378	+2.023	.006	.005	3	2
UCEC	BAG3 →	+0.579	+2.386	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,018 associations by consensus.

RNU1-62P by PAX8 expression — CESC

Explore this box plot interactively →