PAX8

Across TCGA patient cohorts, PAX8 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX8-associated genes across cancer lineages are eEF2, ETS-1, and mTOR_pS2448. Each is linked with PAX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX8-to-partner and partner-to-PAX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PAX8-low versus PAX8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX8→partner) and Y-score (partner→PAX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.454	+3.459	<.001	.005	3	2
UCEC	ETS-1 →	+0.262	+2.115	.032	.017	3	2
UCEC	mTOR_pS2448 →	-0.194	-2.886	<.001	.001	3	2
UCEC	PCNA →	+0.215	+2.087	.009	.005	3	2
UCEC	PEA-15_pS116 →	+0.298	+2.087	.026	.005	3	2
UCEC	PRDX1 →	+0.164	+2.459	.038	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eEF2 by PAX8 expression — UCEC

Explore this box plot interactively →