PAX8

Across TCGA cell cohorts, PAX8 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible PAX8-associated genes across cancer lineages are SFT2D3, ACSM2A, and PRSS48. Each is linked with PAX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX8-to-partner and partner-to-PAX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFT2D3 grouped by PAX8-low versus PAX8-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX8→partner) and Y-score (partner→PAX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SFT2D3 →	+0.779	+4.450	.001	.004	3	1
OVARY	ACSM2A →	+0.088	+4.029	<.001	.009	3	1
OVARY	PRSS48 →	+0.043	+4.029	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.017	+4.662	<.001	.005	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.977	<.001	.007	3	1
BREAST	LHCGR →	+0.033	+4.392	.008	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SFT2D3 by PAX8 expression — OVARY

Explore this box plot interactively →