PAX7

Across TCGA patient cohorts, PAX7 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX7-associated genes across cancer lineages are INPP4B, A-Raf_pS299, and eIF4E. Each is linked with PAX7 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAX7-to-partner and partner-to-PAX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by PAX7-low versus PAX7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX7→partner) and Y-score (partner→PAX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.259	-2.087	.015	.004	3	3
COAD	A-Raf_pS299 →	-0.182	-3.161	.028	.019	3	2
UCEC	eIF4E →	+0.224	+2.263	.001	<.001	2	3
UCEC	GATA6 →	-0.151	-2.444	.004	.018	3	2
UCEC	Notch1 →	+0.141	+2.128	.002	.009	3	2
UCEC	PCNA →	+0.204	+2.263	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

INPP4B by PAX7 expression — UCEC

Explore this box plot interactively →