Across TCGA patient cohorts, PAX5 mutation is significantly associated with the RNA expression of many other genes, with 2,498 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX5-associated genes across cancer lineages are FBXO22, LINC01154, and LEPROTL1. Each is linked with PAX5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAX5-to-partner and partner-to-PAX5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX5→partner) and Y-score (partner→PAX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FBXO22 →	+0.436	+3.290	<.001	<.001	3	3
LUSC	LINC01154 →	+0.146	+3.161	.009	.004	3	3
UCEC	LEPROTL1 →	+0.334	+3.491	.001	.002	3	3
UCEC	MFAP1 →	+0.539	+1.868	<.001	<.001	3	3
UCEC	MTA2 →	+0.319	+2.042	.001	.001	3	2
COAD	HIRIP3 →	+0.489	+3.321	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,498 associations by consensus.

Exploration

PAX5 survival (RNA) · tumor vs normal (RNA) · all PAX5 data types