Across TCGA patient cohorts, PAX5 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX5-associated genes across cancer lineages are P-Cadherin, PCNA, and PDCD4. Each is linked with PAX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX5-to-partner and partner-to-PAX5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX5→partner) and Y-score (partner→PAX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	P-Cadherin →	-0.096	-2.115	.036	.016	3	2
UCEC	PCNA →	+0.190	+1.777	.005	.002	3	2
UCEC	PDCD4 →	-0.533	-1.523	<.001	.008	3	2
UCEC	Rab25 →	-0.220	-1.415	.038	.043	3	2
UCEC	c-Met_pY1235 →	+0.062	+1.746	.009	.003	3	2
UCEC	Cyclin-B1 →	+0.676	+2.058	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

PAX5 survival (RNA) · tumor vs normal (RNA) · all PAX5 data types