Across TCGA cell cohorts, PAX5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAX5-associated genes across cancer lineages are SIGLEC11, CST5, and FAM240B. Each is linked with PAX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX5-to-partner and partner-to-PAX5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX5→partner) and Y-score (partner→PAX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIGLEC11 →	+0.025	+3.584	.001	.007	3	1
BLOOD_Leukemia	CST5 →	+0.395	+3.551	<.001	.009	3	1
BLOOD_Leukemia	FAM240B →	+0.017	+4.384	<.001	.006	3	1
LARGE_INTESTINE	CNR2 →	+0.169	+3.807	<.001	.003	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

PAX5 survival (RNA) · tumor vs normal (RNA) · all PAX5 data types