PAX3

Across TCGA patient cohorts, PAX3 mutation is significantly associated with the RNA expression of many other genes, with 5,575 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX3-associated genes across cancer lineages are METTL17, IER3IP1, and TRMT2A. Each is linked with PAX3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PAX3-to-partner and partner-to-PAX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL17 grouped by PAX3-low versus PAX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX3→partner) and Y-score (partner→PAX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	METTL17 →	+0.293	+1.807	<.001	<.001	3	4
UCEC	IER3IP1 →	+0.363	+1.513	.001	<.001	3	4
UCEC	TRMT2A →	+0.223	+1.423	.005	.006	3	4
STAD	TMEM203 →	+0.414	+3.338	.003	.005	3	3
STAD	RRP7A →	+0.554	+3.186	.003	.009	3	3
UCEC	PRPF39 →	+0.324	+2.119	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,575 associations by consensus.

METTL17 by PAX3 expression — UCEC

Explore this box plot interactively →