PAX3

Across TCGA patient cohorts, PAX3 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX3-associated genes across cancer lineages are GAPDH, ASNS, and ATM. Each is linked with PAX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAX3-to-partner and partner-to-PAX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PAX3-low versus PAX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX3→partner) and Y-score (partner→PAX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.368	+1.678	.017	.019	3	3
UCEC	ASNS →	+0.346	+1.137	<.001	.037	3	3
UCEC	ATM →	-0.567	-1.736	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.329	+3.247	<.001	<.001	3	3
UCEC	14-3-3_beta →	-0.111	-2.780	<.001	<.001	3	2
UCEC	eEF2 →	+0.358	+1.736	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

GAPDH by PAX3 expression — UCEC

Explore this box plot interactively →