PAX3

Across TCGA cell cohorts, PAX3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PAX3-associated genes across cancer lineages are SCGB1C1, RTP2, and C9orf57. Each is linked with PAX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX3-to-partner and partner-to-PAX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1C1 grouped by PAX3-low versus PAX3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX3→partner) and Y-score (partner→PAX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SCGB1C1 →	+0.140	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	RTP2 →	+0.031	+4.459	<.001	.001	3	1
BLOOD_Lymphoma	C9orf57 →	+0.350	+3.954	<.001	.005	3	1
BLOOD_Lymphoma	OR11H2 →	+0.025	+3.927	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SCGB1C1 by PAX3 expression — BLOOD_Lymphoma

Explore this box plot interactively →