PAUPAR

Across TCGA pan-cancer cohorts, PAUPAR RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated PAUPAR data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PAUPAR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PAUPAR expression acts as an unfavorable survival marker, although some lineages such as PAAD and READ show a favorable association.

KIRC, BRCA, and MESO are the cancer types where PAUPAR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.500	0.657	<.001	168	view →
BRCA	OS	Tertile	All	0.846	0.933	<.001	102	view →
MESO	OS	Tertile	All	0.409	0.590	.006	86	view →
ACC	OS	Tertile	All	0.254	0.676	.003	84	view →
LIHC	OS	Tertile	All	0.392	0.705	<.001	75	view →
THCA	DFS	Tertile	All	0.293	0.823	<.001	72	view →
LGG	DFS	Median	All	0.632	0.833	<.001	50	view →
THYM	DFS	Tertile	All	0.111	0.826	<.001	30	view →
SARC	DFS	Tertile	All	0.234	0.422	.003	19	view →
PAAD	DFS	Quartile	All	0.533	0.263	.014	13	view →
LUAD	OS	Tertile	All	0.119	0.364	.032	12	view →
COAD	OS	Tertile	III,IV	0.219	0.698	.048	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

PAUPAR–KIRC (OS)

Open the KIRC breakdown →