PATL2

Across TCGA patient cohorts, PATL2 mutation is significantly associated with the RNA expression of many other genes, with 1,791 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PATL2-associated genes across cancer lineages are PEDS1-UBE2V1, AKR1B1P3, and SNRPGP8. Each is linked with PATL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PATL2-to-partner and partner-to-PATL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEDS1-UBE2V1 grouped by PATL2-low versus PATL2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATL2→partner) and Y-score (partner→PATL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PEDS1-UBE2V1 →	+0.066	+4.051	<.001	.001	3	2
COAD	AKR1B1P3 →	+0.129	+3.564	.008	.002	3	2
COAD	SNRPGP8 →	+0.158	+4.399	<.001	.006	3	2
COAD	UBL5P1 →	+0.411	+3.868	<.001	.003	3	2
UCEC	SRP72P1 →	+0.089	+1.590	.001	.008	3	2
UCEC	IGHD3-16 →	+0.781	+1.648	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,791 associations by consensus.

PEDS1-UBE2V1 by PATL2 expression — COAD

Explore this box plot interactively →