PATL2

Across TCGA patient cohorts, PATL2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PATL2-associated genes across cancer lineages are EGFR_pY1068, MEK1, and PCNA. Each is linked with PATL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PATL2-to-partner and partner-to-PATL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PATL2-low versus PATL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATL2→partner) and Y-score (partner→PATL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.320	-2.662	<.001	<.001	3	2
UCEC	MEK1 →	+0.405	+3.000	.003	<.001	3	2
UCEC	PCNA →	+0.288	+3.087	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.216	-2.169	<.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.478	+2.019	.031	.017	3	2
UCEC	A-Raf_pS299 →	-0.138	-2.459	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

EGFR_pY1068 by PATL2 expression — UCEC

Explore this box plot interactively →