PATJ

Across TCGA patient cohorts, PATJ mutation is significantly associated with the RNA expression of many other genes, with 5,319 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PATJ-associated genes across cancer lineages are CHAF1B, FBXO7, and TXN2. Each is linked with PATJ in more than 5 cancer types. Because this analysis shows association rather than direction, both PATJ-to-partner and partner-to-PATJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1B grouped by PATJ-low versus PATJ-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATJ→partner) and Y-score (partner→PATJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CHAF1B →	+0.702	+2.611	<.001	.006	3	6
SKCM	FBXO7 →	+0.339	+1.672	.007	.006	3	5
UCEC	TXN2 →	+0.313	+1.681	<.001	<.001	3	5
UCEC	LRRC59 →	+0.395	+1.821	<.001	<.001	3	5
UCEC	PPP2CA →	+0.259	+1.959	.001	<.001	3	5
BLCA	MRPL37 →	+0.480	+2.957	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,319 associations by consensus.

CHAF1B by PATJ expression — COAD

Explore this box plot interactively →