PATJ

Across TCGA patient cohorts, PATJ mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PATJ-associated genes across cancer lineages are eEF2, Heregulin, and Cyclin-B1. Each is linked with PATJ in more than 2 cancer types. Because this analysis shows association rather than direction, both PATJ-to-partner and partner-to-PATJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PATJ-low versus PATJ-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PATJ→partner) and Y-score (partner→PATJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	eEF2 →	+0.280	+3.179	.001	.010	3	3
LUSC	Heregulin →	-0.219	-3.000	.023	.035	3	3
LUAD	Cyclin-B1 →	+0.571	+3.000	.034	.036	3	3
COAD	RAD51 →	+0.195	+2.330	.005	.020	3	3
COAD	ATM →	-0.581	-3.000	<.001	.034	3	3
COAD	Caspase-7-cleavedD198 →	+1.805	+3.467	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

eEF2 by PATJ expression — LUSC

Explore this box plot interactively →