PASK

Across TCGA pan-cancer cohorts, PASK mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PASK data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PASK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PASK expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where PASK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.158	0.568	.019	23	view →
HNSC	DFS	Quartile	II,III,IV	0.776	1.000	.008	16	view →
LSCC	OS	Tertile	III,IV	0.795	0.406	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PASK–PDAC (DFS)

Open the PDAC breakdown →