PASK

Across TCGA patient cohorts, PASK mutation is significantly associated with the RNA expression of many other genes, with 5,006 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PASK-associated genes across cancer lineages are ADAM33, ATP5F1A, and SKA1. Each is linked with PASK in more than 2 cancer types. Because this analysis shows association rather than direction, both PASK-to-partner and partner-to-PASK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM33 grouped by PASK-low versus PASK-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PASK→partner) and Y-score (partner→PASK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ADAM33 →	-1.141	-3.807	.001	<.001	3	3
STAD	ATP5F1A →	+0.623	+3.597	<.001	.001	3	3
UCEC	SKA1 →	+0.650	+3.544	<.001	<.001	3	3
UCEC	PKN3 →	+0.775	+2.332	<.001	<.001	3	3
COAD	WDR41 →	+0.488	+3.362	<.001	.004	3	3
UCEC	NUDT2 →	+0.374	+2.534	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,006 associations by consensus.

ADAM33 by PASK expression — STAD

Explore this box plot interactively →