PASK

Across TCGA patient cohorts, PASK mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PASK-associated genes across cancer lineages are Smad4, PCNA, and ASNS. Each is linked with PASK in more than 3 cancer types. Because this analysis shows association rather than direction, both PASK-to-partner and partner-to-PASK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad4 grouped by PASK-low versus PASK-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PASK→partner) and Y-score (partner→PASK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Smad4 →	+0.169	+3.330	.006	.005	3	4
UCEC	PCNA →	+0.208	+1.784	<.001	<.001	3	4
STAD	ASNS →	+0.425	+2.459	.027	.019	3	3
STAD	Bad_pS112 →	-0.275	-3.169	.002	.018	3	3
UCEC	ATM →	-0.452	-1.784	<.001	<.001	3	3
LUSC	AR →	-0.171	-3.000	.021	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Smad4 by PASK expression — COAD

Explore this box plot interactively →