PASK

Across TCGA cell cohorts, PASK mutation is significantly associated with the RNA expression of many other genes, with 469 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PASK-associated genes across cancer lineages are AKAP8L, DCAF10, and KANSL2. Each is linked with PASK in more than 2 cancer types. Because this analysis shows association rather than direction, both PASK-to-partner and partner-to-PASK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKAP8L grouped by PASK-low versus PASK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PASK→partner) and Y-score (partner→PASK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AKAP8L →	+0.492	+2.628	.001	.002	3	2
LARGE_INTESTINE	DCAF10 →	+0.432	+3.169	.004	.009	3	2
LARGE_INTESTINE	KANSL2 →	+0.374	+3.169	.008	.009	3	2
LARGE_INTESTINE	TAF5 →	+0.393	+2.628	.007	.002	3	2
LARGE_INTESTINE	SCAI →	+0.566	+3.169	.001	.009	3	2
LARGE_INTESTINE	ARL13A →	+0.052	+2.714	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 469 associations by consensus.

AKAP8L by PASK expression — LARGE_INTESTINE

Explore this box plot interactively →