PASD1

Across TCGA patient cohorts, PASD1 mutation is significantly associated with the RNA expression of many other genes, with 4,222 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PASD1-associated genes across cancer lineages are PSMC3IP, RNU6-1169P, and MCM5. Each is linked with PASD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PASD1-to-partner and partner-to-PASD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by PASD1-low versus PASD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PASD1→partner) and Y-score (partner→PASD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC3IP →	+0.568	+1.638	<.001	<.001	3	4
COAD	RNU6-1169P →	+0.426	+3.325	<.001	.003	3	4
UCEC	MCM5 →	+0.440	+1.470	.001	<.001	3	3
UCEC	CUEDC2 →	+0.321	+1.423	.004	.006	3	3
UCEC	NSD2 →	+0.412	+1.310	<.001	.002	3	3
UCEC	CCDC86 →	+0.438	+1.491	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,222 associations by consensus.

PSMC3IP by PASD1 expression — UCEC

Explore this box plot interactively →