PARVG

Across TCGA patient cohorts, PARVG mutation is significantly associated with the RNA expression of many other genes, with 1,602 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARVG-associated genes across cancer lineages are MYL1, KNOP1, and GFOD2. Each is linked with PARVG in more than 1 cancer types. Because this analysis shows association rather than direction, both PARVG-to-partner and partner-to-PARVG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYL1 grouped by PARVG-low versus PARVG-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARVG→partner) and Y-score (partner→PARVG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	MYL1 →	+0.411	+4.502	<.001	.004	3	2
UCEC	KNOP1 →	+0.559	+2.769	<.001	<.001	3	2
SKCM	GFOD2 →	+0.466	+3.226	.008	.009	3	2
UCEC	RTCB →	+0.498	+2.961	.001	<.001	3	2
UCEC	WDR59 →	+0.336	+1.847	.005	.009	3	2
UCEC	OIP5 →	+0.646	+2.923	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,602 associations by consensus.

MYL1 by PARVG expression — SCLC

Explore this box plot interactively →