PARVG

Across TCGA patient cohorts, PARVG mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARVG-associated genes across cancer lineages are MSH2, Annexin_VII, and Di-Ras3. Each is linked with PARVG in more than 1 cancer types. Because this analysis shows association rather than direction, both PARVG-to-partner and partner-to-PARVG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by PARVG-low versus PARVG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARVG→partner) and Y-score (partner→PARVG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.243	-3.295	.010	.009	3	2
UCEC	Annexin_VII →	-0.125	-2.321	.028	.006	3	2
UCEC	Di-Ras3 →	-0.165	-3.459	.006	.005	3	2
UCEC	14-3-3_beta →	-0.123	-3.432	.003	.005	3	1
UCEC	A-Raf_pS299 →	-0.110	-2.321	.025	.034	3	1
UCEC	MEK1 →	+0.317	+2.584	.036	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MSH2 by PARVG expression — UCEC

Explore this box plot interactively →