PARVG

Across TCGA cell cohorts, PARVG mutation is significantly associated with the mutation status of many other genes, with 5,132 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARVG-associated genes across cancer lineages are GABRG1, PIGV, and TSPOAP1. Each is linked with PARVG in more than 3 cancer types. Because this analysis shows association rather than direction, both PARVG-to-partner and partner-to-PARVG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRG1 grouped by PARVG-low versus PARVG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARVG→partner) and Y-score (partner→PARVG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GABRG1 →	+2.824	+3.925	<.001	<.001	1	4
LUNG_SCLC	PIGV →	+5.502	+5.502	.003	.003	1	3
SKIN	TSPOAP1 →	+3.245	+4.807	<.001	<.001	1	3
SKIN	ADCY2 →	+3.731	+5.133	<.001	<.001	1	3
SKIN	ATG2A →	+3.245	+4.807	<.001	<.001	1	3
STOMACH	LRP10 →	+4.807	+4.807	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,132 associations by consensus.

GABRG1 by PARVG expression — LARGE_INTESTINE

Explore this box plot interactively →