PARVG

Across TCGA cell cohorts, PARVG mutation is significantly associated with the drug of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARVG-associated genes across cancer lineages are Temsirolimus, Lestaurtinib, and Cetuximab. Each is linked with PARVG in more than 1 cancer types. Because this analysis shows association rather than direction, both PARVG-to-partner and partner-to-PARVG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Temsirolimus grouped by PARVG-low versus PARVG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARVG→partner) and Y-score (partner→PARVG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Temsirolimus →	+0.599	+2.871	.005	.021	3	1
LARGE_INTESTINE	Lestaurtinib →	+0.557	+2.932	.017	.019	3	1
LARGE_INTESTINE	Cetuximab →	+0.488	+2.655	.048	.044	3	1
LARGE_INTESTINE	AZD7969 →	+0.467	+2.871	.031	.021	3	1
LARGE_INTESTINE	GSK2801 →	+0.330	+3.064	.021	.009	3	1
LARGE_INTESTINE	JQ1 →	+0.570	+2.807	.020	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Temsirolimus by PARVG expression — LARGE_INTESTINE

Explore this box plot interactively →