Across TCGA patient cohorts, PARVA mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARVA-associated genes across cancer lineages are Ku80, 14-3-3_beta, and EGFR. Each is linked with PARVA in more than 1 cancer types. Because this analysis shows association rather than direction, both PARVA-to-partner and partner-to-PARVA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARVA→partner) and Y-score (partner→PARVA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.194	+1.498	.041	.036	3	2
UCEC	14-3-3_beta →	-0.104	-2.432	.010	.018	3	1
UCEC	EGFR →	-0.214	-3.295	<.001	.009	3	1
UCEC	ERK2 →	+0.213	+2.415	.006	.003	3	1
UCEC	FASN →	+0.405	+2.000	.010	.030	3	1
UCEC	FoxM1 →	+0.231	+2.415	.026	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

PARVA survival (RNA) · tumor vs normal (RNA) · all PARVA data types