PARS2

Across TCGA patient cohorts, PARS2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARS2-associated genes across cancer lineages are EGFR, INPP4B, and JNK2. Each is linked with PARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARS2-to-partner and partner-to-PARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by PARS2-low versus PARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARS2→partner) and Y-score (partner→PARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.245	-3.143	<.001	.018	3	1
UCEC	INPP4B →	-0.325	-3.459	.025	.005	3	1
UCEC	JNK2 →	+0.200	+2.000	.025	.032	3	1
UCEC	Ku80 →	+0.292	+3.183	.006	.009	3	1
UCEC	MEK1 →	+0.375	+3.459	.022	.005	3	1
UCEC	S6_pS240_S244 →	+0.452	+3.000	.013	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR by PARS2 expression — UCEC

Explore this box plot interactively →