PARS2

Across TCGA cell cohorts, PARS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,629 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARS2-associated GO terms across cancer lineages are RNA 3'-end processing, Regulation of translational fidelity, and snRNA processing. Each is linked with PARS2 in more than 11 cancer types. Because this analysis shows association rather than direction, both PARS2-to-partner and partner-to-PARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA 3'-end processing grouped by PARS2-low versus PARS2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARS2→partner) and Y-score (partner→PARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNA 3'-end processing →	+0.075	+0.628	<.001	<.001	3	12
PANCREAS	Regulation of translational fidelity →	+0.089	+0.609	<.001	<.001	3	11
BONE	snRNA processing →	+0.083	+0.524	<.001	<.001	3	11
BLOOD_Lymphoma	Regulation of DNA-templated transcription elongation →	+0.065	+0.579	<.001	<.001	3	11
BLOOD_Lymphoma	Positive regulation of mRNA metabolic process →	+0.051	+0.430	.001	.001	3	11
BONE	Mitochondrial RNA catabolic process →	+0.116	+0.693	.003	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,629 associations by consensus.

RNA 3'-end processing by PARS2 expression — BONE

Explore this box plot interactively →