PARS2

Across TCGA cell cohorts, PARS2 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARS2-associated genes across cancer lineages are RIMS4, EPPIN, and GLRA2. Each is linked with PARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARS2-to-partner and partner-to-PARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIMS4 grouped by PARS2-low versus PARS2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARS2→partner) and Y-score (partner→PARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RIMS4 →	+0.214	+3.675	.002	.003	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+3.507	<.001	.004	3	1
BLOOD_Leukemia	GLRA2 →	+0.021	+4.054	.001	.004	3	1
BLOOD_Leukemia	NPTX2 →	+1.564	+3.415	<.001	.007	3	1
BLOOD_Leukemia	PHOX2B →	+0.017	+3.365	<.001	.005	3	1
BLOOD_Leukemia	NUDT10 →	+1.111	+3.491	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

RIMS4 by PARS2 expression — BLOOD_Leukemia

Explore this box plot interactively →