PARP4

Across TCGA patient cohorts, PARP4 mutation is significantly associated with the RNA expression of many other genes, with 4,812 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP4-associated genes across cancer lineages are SMIM4, ZFP3, and BTBD6. Each is linked with PARP4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PARP4-to-partner and partner-to-PARP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM4 grouped by PARP4-low versus PARP4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP4→partner) and Y-score (partner→PARP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SMIM4 →	+0.442	+2.826	.006	.001	3	4
UCEC	ZFP3 →	-0.696	-1.830	<.001	<.001	3	3
SKCM	BTBD6 →	+0.452	+2.725	.002	.002	3	3
COAD	GAS2L1 →	+0.917	+3.459	<.001	.005	3	3
UCEC	NF2 →	+0.461	+2.244	<.001	<.001	3	3
UCEC	GPATCH3 →	+0.308	+2.566	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,812 associations by consensus.

SMIM4 by PARP4 expression — SKCM

Explore this box plot interactively →