PARP4

Across TCGA patient cohorts, PARP4 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP4-associated genes across cancer lineages are B-Raf, Chk2_pT68, and VEGFR2. Each is linked with PARP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PARP4-to-partner and partner-to-PARP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B-Raf grouped by PARP4-low versus PARP4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP4→partner) and Y-score (partner→PARP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	B-Raf →	+0.494	+2.331	.007	.019	3	2
UCEC	Chk2_pT68 →	-0.119	-2.295	.031	.033	3	2
BLCA	VEGFR2 →	+0.297	+1.999	.039	.031	3	2
COAD	Caspase-7-cleavedD198 →	+1.178	+2.824	.001	.034	3	2
COAD	C-Raf →	+0.194	+2.178	.004	.035	2	3
UCEC	14-3-3_beta →	-0.067	-1.880	.025	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

B-Raf by PARP4 expression — LUSC

Explore this box plot interactively →