PARP3

Across TCGA pan-cancer cohorts, PARP3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PARP3 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PARP3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PARP3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC and LUAD are the cancer types where PARP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.404	1.000	.007	7	view →
LUAD	DFS	Tertile	II,III,IV	0.733	0.233	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PARP3–LSCC (OS)

Open the LSCC breakdown →