PARP3

Across TCGA patient cohorts, PARP3 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP3-associated genes across cancer lineages are eEF2, eIF4E, and PCNA. Each is linked with PARP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP3-to-partner and partner-to-PARP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PARP3-low versus PARP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP3→partner) and Y-score (partner→PARP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.298	+2.321	.018	.033	3	2
UCEC	eIF4E →	+0.201	+3.472	.006	.002	3	2
UCEC	PCNA →	+0.238	+2.502	.001	.001	3	2
UCEC	TFRC →	+0.508	+1.662	.006	.011	3	2
UCEC	c-Kit →	-0.180	-1.362	.029	.037	3	2
UCEC	4E-BP1 →	+0.349	+2.000	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eEF2 by PARP3 expression — UCEC

Explore this box plot interactively →