PARP2

Across TCGA patient cohorts, PARP2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,444 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PARP2-associated genes across cancer lineages are CCNB1IP1, LRR1, and METTL3. Each is linked with PARP2 in more than 7 cancer types. Because this analysis shows association rather than direction, both PARP2-to-partner and partner-to-PARP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PARP2 versus CCNB1IP1 in BRCA, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP2→partner) and Y-score (partner→PARP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCNB1IP1 →	+0.799	+0.420	<.001	<.001	3	8
HNSC	LRR1 →	+0.672	+0.281	.001	.001	3	7
HNSC	METTL3 →	+0.631	+0.254	.001	.004	3	7
GBM	KNTC1 →	+0.676	+0.394	<.001	.001	3	7
COAD	MTHFD1 →	+0.853	+0.675	<.001	<.001	3	6
LSCC	VRK1 →	+0.908	+0.414	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,444 associations by consensus.

PARP2 vs CCNB1IP1 — BRCA

Explore this scatter interactively →