PARP2

Across TCGA patient cohorts, PARP2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP2-associated genes across cancer lineages are PKC-delta_pS664, ATM, and 14-3-3_beta. Each is linked with PARP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP2-to-partner and partner-to-PARP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by PARP2-low versus PARP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP2→partner) and Y-score (partner→PARP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.093	-2.459	.042	.018	3	2
UCEC	ATM →	-0.571	-1.678	.001	.023	3	2
UCEC	14-3-3_beta →	-0.099	-3.558	.010	.002	3	1
UCEC	eEF2 →	+0.282	+2.999	.039	.035	3	1
UCEC	eIF4E →	+0.190	+3.335	.018	.005	3	1
UCEC	A-Raf_pS299 →	-0.151	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PKC-delta_pS664 by PARP2 expression — UCEC

Explore this box plot interactively →