PARP2

Across TCGA cell cohorts, PARP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,459 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARP2-associated GO terms across cancer lineages are Interstrand cross-link repair, DNA-templated DNA replication maintenance of fidelity, and DNA replication-dependent chromatin assembly. Each is linked with PARP2 in more than 18 cancer types. Because this analysis shows association rather than direction, both PARP2-to-partner and partner-to-PARP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interstrand cross-link repair grouped by PARP2-low versus PARP2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP2→partner) and Y-score (partner→PARP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Interstrand cross-link repair →	+0.084	+1.132	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.095	+1.006	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA replication-dependent chromatin assembly →	+0.124	+1.020	<.001	<.001	3	17
KIDNEY	Regulation of chromosome separation →	+0.119	+0.858	.007	.004	3	17
PANCREAS	Chromosome condensation →	+0.144	+0.684	.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.057	+0.902	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,459 associations by consensus.

Interstrand cross-link repair by PARP2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →