PARP2

Across TCGA cell cohorts, PARP2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARP2-associated genes across cancer lineages are MSGN1, KRTAP10-2, and RPL10L. Each is linked with PARP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP2-to-partner and partner-to-PARP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by PARP2-low versus PARP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP2→partner) and Y-score (partner→PARP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.061	+3.994	<.001	.002	3	1
BLOOD_Lymphoma	RPL10L →	+0.181	+4.191	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MSGN1 by PARP2 expression — LARGE_INTESTINE

Explore this box plot interactively →