PARP16

Across TCGA patient cohorts, PARP16 mutation is significantly associated with the RNA expression of many other genes, with 656 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP16-associated genes across cancer lineages are UBE2L3, LONP1, and DNAJA1P1. Each is linked with PARP16 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP16-to-partner and partner-to-PARP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2L3 grouped by PARP16-low versus PARP16-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP16→partner) and Y-score (partner→PARP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	UBE2L3 →	+0.431	+3.240	.002	.009	3	2
UCEC	LONP1 →	+0.716	+2.649	<.001	.005	3	2
BLCA	DNAJA1P1 →	+0.034	+4.497	<.001	.009	3	2
HNSC	RPS29P33 →	+0.238	+5.368	.001	.005	3	2
UCEC	MON1A →	+0.511	+3.711	<.001	<.001	3	2
UCEC	CHAF1A →	+0.588	+2.721	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 656 associations by consensus.

UBE2L3 by PARP16 expression — SKCM

Explore this box plot interactively →