PARP16

Across TCGA cell cohorts, PARP16 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,114 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PARP16-associated GO terms across cancer lineages are Regulation of heterochromatin organization, Regulation of hemostasis, and Regulation of nucleotide-excision repair. Each is linked with PARP16 in more than 9 cancer types. Because this analysis shows association rather than direction, both PARP16-to-partner and partner-to-PARP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of heterochromatin organization grouped by PARP16-low versus PARP16-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP16→partner) and Y-score (partner→PARP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of heterochromatin organization →	+0.081	+0.676	<.001	<.001	3	10
BONE	Regulation of hemostasis →	-0.157	-0.534	<.001	<.001	3	9
BONE	Regulation of nucleotide-excision repair →	+0.129	+0.681	<.001	<.001	3	9
BONE	Regulation of blood coagulation →	-0.154	-0.534	<.001	<.001	3	9
BONE	Positive regulation of DNA repair →	+0.058	+0.529	<.001	<.001	3	9
PANCREAS	Negative regulation of polyamine transmembrane transport →	+0.104	+0.782	.002	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,114 associations by consensus.

Regulation of heterochromatin organization by PARP16 expression — URINARY_TRACT

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