PARP12

Across TCGA pan-cancer cohorts, PARP12 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PARP12 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PARP12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PARP12 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

COAD, LUAD, and HNSC are the cancer types where PARP12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.831	1.000	.022	42	view →
LUAD	DFS	Median	III,IV	0.974	0.545	.002	29	view →
HNSC	DFS	Median	III,IV	0.860	0.361	.022	7	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	4	view →
PDAC	DFS	Tertile	II,III,IV	0.637	0.846	.014	2	view →
LSCC	OS	Quartile	II,III,IV	0.522	0.852	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PARP12–COAD (DFS)

Open the COAD breakdown →