PARP12

Across TCGA patient cohorts, PARP12 mutation is significantly associated with the RNA expression of many other genes, with 3,725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP12-associated genes across cancer lineages are CDH18-AS1, CHUK, and NARS1. Each is linked with PARP12 in more than 2 cancer types. Because this analysis shows association rather than direction, both PARP12-to-partner and partner-to-PARP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH18-AS1 grouped by PARP12-low versus PARP12-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP12→partner) and Y-score (partner→PARP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CDH18-AS1 →	+0.919	+5.685	<.001	.003	3	3
SKCM	CHUK →	+0.580	+3.019	.002	<.001	3	3
UCEC	NARS1 →	+0.494	+3.016	<.001	<.001	3	3
UCEC	ME2 →	+0.487	+2.010	.001	.001	3	3
UCEC	SFMBT2 →	+0.330	+2.616	.007	.005	3	3
UCEC	IGHD4-17 →	+0.512	+2.299	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,725 associations by consensus.

CDH18-AS1 by PARP12 expression — BLCA

Explore this box plot interactively →