PARP12

Across TCGA patient cohorts, PARP12 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP12-associated genes across cancer lineages are c-Met, MEK1, and mTOR_pS2448. Each is linked with PARP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP12-to-partner and partner-to-PARP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met grouped by PARP12-low versus PARP12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP12→partner) and Y-score (partner→PARP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met →	-0.236	-3.247	.039	<.001	3	2
UCEC	MEK1 →	+0.459	+3.584	.001	.002	3	2
UCEC	mTOR_pS2448 →	-0.119	-2.439	.037	.019	3	2
SKCM	IRS1 →	+0.179	+2.321	.019	.035	3	1
SKCM	NDRG1_pT346 →	-0.754	-3.000	.021	.034	3	1
SKCM	eEF2K →	+0.405	+2.820	.020	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

c-Met by PARP12 expression — UCEC

Explore this box plot interactively →